Understanding how cells copy and preserve their DNA
The replisome in ink on paper (author: Eric Reyes)
The Reyes Lab has a broad interest in DNA. We study the machinery that copies DNA (the replisome), the control of DNA replication, the response of cells to DNA damage, and the interaction of transcription factors with DNA.
We use single-molecule fluorescence microscopy, genetics, and biochemistry in bacteria and yeast to study relevant cellular processes. Our work has implications in the search of new antibiotic targets, the understanding of cancer and other genetic diseases, biotechnological applications, and the search of life in the universe.
CHECK OUT OUR LATEST PAPER:
Kapadia N, El-Hajj ZW, Reyes-Lamothe R (2021)
Bound2Learn: a machine learning approach for classification of DNA-bound proteins from single-molecule tracking experiments Nucleic Acid Res. doi: 10.1093/nar/gkab186.
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